A Peabody Award-winning filmmaker, Senain has directed several feature and short films, including the three-time Emmy-nominated feature documentary THE DIPLOMAT (ESPN), and the award-winning PROJECT KASHMIR (PBS/Independent Lens). She created, wrote and directed the comedic docu-web series DIVAS OF KARACHI (PBS/ITVS) and directed virtual reality films with Here Be Dragons (formerly Vrse) for Facebook, Johnson & Johnson, and Save the Children. She was commissioned by The Annenberg Center for Photography to make a VR film in Havana, Cuba as part of the Pacific Standard Time exhibition. Her films have premiered at Tribeca Film Festival, International Documentary Festival Amsterdam (IDFA), The Human Rights Watch Film Festival (NY and London) as well as other film festivals around the world.

Senain is a three-time Sundance Fellow and has served on panels and juries at Sundance, Hot Docs, Sheffield Doc/Fest, ITVS, and Film Independent. She is a former board member of the International Documentary Association and a member of the Academy of Motion Picture Arts and Sciences.