Cannabinoid Conundrum: A Study of Anti-Epileptic Efficacy and Drug Policy

10:00 AM, Saturday 9 Nov 2019 (50 minutes)
Bayside A
Scientific research needs to be a key factor in the creation of new marijuana policy. In an effort to explore the antiepileptic efficacy of the first ever marijuana-derived drug, Epidiolex (cannabidiol or CBD), this study utilized a zebrafish model of Dravet Syndrome. About 80% of Dravet Syndrome patients carry a mutation in the voltage-gated sodium channel Nav1.1 (scn1a). scn1a mutant zebrafish underwent both acute and subchronic exposures to various concentrations of CBD. CBD was found to significantly decrease seizure activity within the acute exposure. To provide context and relevancy to this research, the complicated legal status of marijuana is discussed, and potential reform options are provided as advocacy for policy change.
University of Mississippi

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