On April 2022, Elon Musk noted that: “At this point, I think I know more about manufacturing tan anyone currently alive on Earth”. Why did he say so? What can be learned from his “Alien” and “Dreadnought” factories? This session will elaborate on the current state of the art on Industrial AI, Digital Twins and Industrial Metaverse and the advances to be seen. Experiences from H2020 Star, HE Circular TAIn and HE RE4DY will be introduced to profile the most updated topics in IIoT-related digital technologies.