Annalisa Trama is the Director of the Evaluative Epidemiology Unit at the Fondazione IRCCS Istituto Nazionale Tumori (INT), Milan, Italy.

Her research activities focus on rare cancers and adolescent and young adult cancers. She is an expert in population-based research including population-based cancer registries and administrative datasets. She was a founder of RARECARE (surveillance of rare cancers in Europe) which proposed a definition for rare cancer. She was the founder of RARECAREnet Asia, a collaboration between European and Asian population-based cancer registries (CRs) on rare cancers. In the area of rare cancers, she co-coordinated the Joint Action on Rare Cancers (JARC), carried out between 2016 and 2019 within the framework of the Third Health Programme of the European Union (EU) with 34 partners and 18 EU Member States. She coordinates the clinical registry of EURACAN, the European Reference Network on rare adult solid cancers. She was a founder of the first Italian adolescent and young (AYA) cancer survivor cohort and she coordinate the Steering committee of this cohort. She is a member of the Scientific Coordination of EUROCARE (surveillance of cancer patients in Europe). She is PI of national and international projects exploiting secondary use of real-world data (e.g. electronic health record, administrative database, clinical registries, population-based registries) and use of innovative solutions (e.g. data fusion; AI approach for defining causal relationship; AI solution to support interoperability of data sources).

She is (co)author of more than 100 papers in peer-reviewed medical journals.