The James Webb Space Telescope is the successor to the Hubble Space Telescope. It is the largest space telescope ever constructed, giving humanity its first high-definition view of the infrared universe. The Webb observes early epochs of the universe that the Hubble cannot see to reveal how its galaxies and structure have evolved over time. The Webb is exploring how stars and planetary systems form and evolve and is searching exoplanet atmospheres for evidence of life. The Webb’s science instrument payload includes four sensor systems that provide imagery, coronagraphy, and spectroscopy over the near- and mid-infrared spectrum. NASA developed the JWST in partnership with the European and Canadian Space Agencies, with science observations proposed by the international astronomical community in a manner like the Hubble. Launch of the Webb occurred during Christmas day 2021. In-flight commissioning was completed during June 2022 and science operations are now underway.