Authors: Steve A. Arshinoff, Tina Felfeli, Milad Modabber

Author Disclosure Block: S.A. Arshinoff: Consultant; Alcon, Rayner, Zeiss, Arctic Dx. T. Felfeli: None. M. Modabber: None.

Purpose: Mathematical models of intracameral antibiotic concentration decay in the anterior chamber compared to resistance levels were created to better understand the duration of antibacterial efficacy of intracameral administration of prophylactic antibiotics. 

Study Design: The resultant graphs were developed from available literature data on injected antibiotic doses, the mechanisms of action of different drugs, logarithmic decay mathematics and reported levels of resistance of bacteria causing endophthalmitis.

Methods: Models of aqueous turnover were applied to intracameral antibiotics and administration techniques, and the results studied to enhance our understanding of IC antibiotic decay in the AC. The three commonly used IC antibiotics were compared. 

Results: Graphs of antibiotic concentration decay were drawn illustrating what happens under various assumptions. The results will be compared to experimental data from the literature. 

Conclusions: The study of models of intracameral antibiotic concentration decay can enhance our understanding of the effects of our current protocols and suggest better practices.